ALEXIS Biochemicals: AMI-1

ALX-270-440

Revised 20-Nov-08

AMI-1
SYNONYMS	Arginine N-Methyltransferase Inhibitor-1
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	PRMTs, Mono- & Dimethylarginine / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-440-M005		5 mg	90.00 USD
ALX-270-440-M025		25 mg	360.00 USD

Product Specification

FORMULA:	C₂₁H₁₂N₂O₉S₂Na₄
MW:	592.4
PURITY:	≥98% (¹H-NMR and HPLC)
APPEARANCE:	Brown solid.
SOLUBILITY:	Soluble in water, 100% ethanol or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Protect from light. Hygroscopic.

Product Description

Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC₅₀=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC₅₀=5.0µM).

Product Specific Literature References

A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) Abstract
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) Abstract; Full Text

Further Categories Containing This Product:

HIV / AIDS / Related Products

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