© 2008 Alexis Corporation
ALX-270-462
Revised 09-Oct-07
AS-605240
SYNONYMS
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-462-M001
1 mg
25.00 USD
ALX-270-462-M005
5 mg
80.00 USD
ALX-270-462-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
12
H
7
N
3
O
2
S
MW:
257.3
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
Pink to reddish brown solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.
Product Specific Literature References
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis:
M. Camps, et al.; Nat. Med.
11
, 936 (2005)
Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus:
D.F. Barber, et al.; Nat. Med.
11
, 933 (2005)
Abstract
© 2008 ALEXIS Corporation,
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