© 2008 Alexis Corporation
ALX-270-073
Revised 15-Dec-06
1400W . dihydrochloride
SYNONYMS
N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-073-M005
5 mg
50.00 USD
ALX-270-073-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
10
H
15
N
3
. 2HCl
MW:
177.3 . 73.0
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II)
in vitro
and
in vivo.
Product Specific Literature References
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo:
E.P. Garvey, et al.; J. Biol. Chem.
272
, 4959 (1997)
Abstract
;
Full Text
Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor:
L.L. Thomsen, et al.; Cancer Res.
57
, 3300 (1997)
Abstract
Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon:
F. Laszlo & B.J.R. Whittle; Eur. J. Pharmacol.
334
, 99 (1997)
Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes:
R. Boer, et al.; Mol. Pharmacol.
58
, 1026 (2000)
Abstract
;
Full Text
Nitric oxide synthases: structure, function and inhibition:
W.K. Alderton, et al.; Biochem. J.
357
, 593 (2001), Review
Abstract
;
Full Text
Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways:
E. Gumpricht, et al.; J. Biol. Chem.
277
, 25823 (2002)
Abstract
;
Full Text
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms:
R. Fedorov, et al.; J. Biol. Chem.
278
, 45818 (2003)
Abstract
;
Full Text
Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes:
X. Cheng & C.C. Pang; Eur. J. Pharmacol.
484
, 263 (2004)
Abstract
1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats:
M. Jafarian-Tehrani, et al.; Nitric Oxide
12
, 61 (2005)
Abstract
Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle:
J.U. Barker, et al.; Microsurgery
25
, 338 (2005)
Abstract
Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa:
Y. Chiba, et al.; Nitric Oxide
15
, 142 (2006)
Abstract
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