© 2008 Alexis Corporation
ALX-270-443
Revised 05-May-08
AS601245
SYNONYMS
1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile
JNK Inhibitor V
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
JNK [SAPK1] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-443-M001
1 mg
50.00 USD
ALX-270-443-M005
5 mg
150.00 USD
ALX-270-443-M025
25 mg
520.00 USD
Product Specification
FORMULA:
C
20
H
16
N
6
S
MW:
372.5
CAS NUMBER:
345987-15-7
PURITY:
≥95% (HPLC)
APPEARANCE:
White to yellow solid.
PURITY DETAIL:
Sum of two isomers.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Hygroscopic. Packaged under inert gas. Protect from light.
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC
50
=150nM, hJNK2: IC
50
=220nM and hJNK3: IC
50
=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
Product Specific Literature References
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties:
S. Carboni, et al.; J. Pharmacol. Exp. Ther.
310
, 25 (2004)
Abstract
;
Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase:
P. Gaillard, et al.; J. Med. Chem.
48
, 4596 (2005)
Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Anti-inflammatory Agents Other Products
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