© 2008 Alexis Corporation
ALX-270-022
Revised 09-Jan-08
AEBSF . hydrochloride
SYNONYMS
4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc
®
SC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-022-M050
50 mg
40.00 USD
ALX-270-022-M250
250 mg
145.00 USD
ALX-270-022-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
8
H
10
FNO
2
S . HCl
MW:
203.2 . 36.5
CAS NUMBER:
30827-99-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No.
ALX-270-184
). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide:
B.R. Baker & H.J. Cory; J. Med. Chem.
14
, 119 (1971)
Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide:
P. Megyeri, et al.; Immunology
86
, 629 (1995)
Abstract
;
Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF:
M. Citron, et al.; Neuron
17
, 171 (1996)
Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor:
Y. Nakabo & M.J. Pabst; J. Leukoc. Biol.
60
, 328 (1996)
Abstract
;
Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds:
V. Diatchuk, et al.; J. Biol. Chem.
272
, 13292 (1997)
Abstract
;
Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening:
P. Megyeri, et al.; Eur. J. Pharmacol.
374
, 207 (1999)
Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis:
R. Buitrago-Rey, et al.; J. Antimicrob. Chemother.
49
, 871 (2002)
Abstract
;
Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes:
N. Wijayanti, et al.; J. Biol. Chem.
280
, 21820 (2005)
Abstract
;
Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression:
T. Hosoi, et al.; Eur. J. Pharmacol.
554
, 8 (2007)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
MAPK Pathway Activators
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
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