© 2008 Alexis Corporation
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
Natural Products - Protein Kinase Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
•
NF-kB Pathway Inhibitors
•
Lipoxygenases / Related Products
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