ALEXIS Biochemicals: Polyclonal Antibody to WIPI-1 (AT130)

ALX-210-955

Revised 11-Mar-08

Polyclonal Antibody to WIPI-1 (AT130)
SYNONYMS	anti-WD Repeat Domain Phosphoinositide-interacting Protein 1 PAb (AT130) anti-WD40 Repeat Protein Interacting with Phosphoinositides of 49kDa PAb (AT130) anti-WIPI 49kDa PAb (AT130) anti-Atg18 Protein Homolog PAb (AT130)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Autophagy-related Proteins [APG; ATG] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-955-C100		100 µg	350.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	0.5mg/ml
PURITY:	Epitope-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa in the middle of human WIPI-1.
SPECIFICITY:	Recognizes human and mouse WIPI-1.
APPLICATION:	Western blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007) Abstract