© 2008 Alexis Corporation
ALX-380-274
Revised 21-May-08
Erythromycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Inflammation Research
Ordering Information
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Format:
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ALX-380-274-G005
5 g
40.00 USD
Product Specification
FORMULA:
C
37
H
67
NO
13
MW:
733.9
CAS NUMBER:
114-07-8
MERCK INDEX:
14:
3681
RTECS:
KF4375000
SOURCE/HOST:
Isolated from
Streptomyces erythreus
.
PURITY:
≥85% (Assay on dry basis)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml), 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Macrolide antibiotic. Inhibits protein synthesis (elongation) at the transpeptidation step. Binds to the 23S RNA of the 50S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
Inducible erythromycin resistance in bacteria:
B. Weisblum; Br. Med. Bull.
40
, 47 (1984)
Abstract
Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells:
Y. Aoki & P.N. Kao; Antimicrob. Agents Chemother.
43
, 2678 (1999)
Abstract
;
Full Text
Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban:
J.Q. Tran, et al.; J. Clin. Pharmacol.
39
, 513 (1999)
Abstract
Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism:
T. Tokairin, et al.; Br. J. Clin. Pharmacol.
60
, 172 (2005)
Abstract
;
Full Text
Related Products
ALX-380-264
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Further Categories Containing This Product:
Translation Inhibitors
•
NF-kB Pathway Inhibitors
•
Anti-inflammatory Agents Other Products
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