ALEXIS Biochemicals: (-)-Menthol

ALX-420-042

Revised 18-Jun-08

(-)-Menthol
SYNONYMS	(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol 5-Methyl-2-(1-methylethyl)cyclohexanol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-042-M025		25 mg	30.00 USD
ALX-420-042-M100		100 mg	75.00 USD

Product Specification

FORMULA:	C₁₀H₂₀O
MW:	156.3
CAS NUMBER:	2216-51-5
MERCK INDEX:	14: 5837
RTECS:	OT0700000
PURITY:	≥98% (sum of enantiomers, GC)
APPEARANCE:	Colorless to white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol or methanol (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Limited shelf life.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.

Product Specific Literature References

Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002) Abstract
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004) Abstract; Full Text
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review Abstract
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006) Abstract
Bimodal action of menthol on the transient receptor potential channel TRPA1: Y. Karashima, et al.; J. Neurosci. 27, 9874 (2007) Abstract
The menthol receptor TRPM8 is the principal detector of environmental cold: D.M. Bautista, et al.; Nature 448, 204 (2007) Abstract

ALX-420-037	Icilin
ALX-420-041	WS-12