© 2008 Alexis Corporation
ALX-350-274
Revised 16-Jun-08
Myriocin
SYNONYMS
ISP-1
Thermozymocidin
2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Immunomodulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-274-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
21
H
39
NO
6
MW:
401.5
CAS NUMBER:
35891-70-4
RTECS:
JX3890000
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No.
ALX-380-002
). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (K
i
=0.28nM). Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC
50
=15nM).
Product Specific Literature References
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite:
T. Fujita, et al.; J. Antibiot.
47
, 208 (1994)
Abstract
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin:
Y. Miyake, et al.; BBRC
211
, 396 (1995)
Abstract
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells:
S. Furuya, et al.; J. Neurochem.
71
, 366 (1998)
Abstract
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells
:
K. Hidari, et al.; J. Biol. Chem.
271
, 14636 (1996)
Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast:
Y. Sun, et al.; Mol. Cell. Biol.
20
, 4411 (2000)
Abstract
;
Full Text
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice:
M.R. Hojjati, et al.; J. Biol. Chem.
280
, 10284 (2005)
Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model:
T. Umehara, et al.; BBRC
346
, 67 (2006)
Abstract
Related Products
ALX-420-043
FTY720
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Sphingolipids & Glycosphingolipids Other Products
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