ALEXIS Biochemicals: Fn14 (human):Fc (human) (recombinant)

ALX-522-086

Revised 08-Jan-07

Fn14 (human):Fc (human) (recombinant)
SYNONYMS	TWEAK-R (human):Fc (human) (recombinant) TNFRSF 12A (human):Fc (human) (recombinant) Fibroblast Growth Factor-inducible Immediate-early Response Protein 14 (human):Fc (human) (recombinant) CD266 (human):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	TWEAK & FN14 / DR3 / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-086-C050		50 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
MW:	~36kDa for the chimeric protein (SDS-PAGE).
SOURCE/HOST:	Produced in HEK 293 cells. The extracellular domain of human Fn14 (aa 1-75) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	>95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg (LAL test; BioWhittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY:	Binds human and mouse TWEAK.
BIOLOGICAL ACTIVITY:	Inhibits TWEAK-mediated killing of Kym-1 target cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least six months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Product Specific Literature References

Intraovarian TWEAK/Fn14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization: A. De, et al.; Mol. Endocrinol. 20, 2528 (2006) Abstract; Full Text

General Information

The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 binds to TWEAK [Apo-3 Ligand], a member of the TNF family.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis: S.R. Wiley, et al.; Immunity 15, 837 (2001) Abstract
The molecular architecture of the TNF superfamily: J.L. Bodmer, et al.; TIBS 27, 19 (2002) Abstract

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.