ALEXIS Biochemicals: Monoclonal Antibody to Fibulin-1 (human) (MEM-2)

ALX-804-622

Revised 23-Apr-08

Monoclonal Antibody to Fibulin-1 (human) (MEM-2)
SYNONYMS	anti-Basement-membrane Protein 90 (human) MAb (MEM-2) anti-BM-90 (human) MAb (MEM-2)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	Cytoskeleton & Extracellular Matrix Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-622-C050		50 µg	210.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	MEM-2
ISOTYPE:	Mouse IgM
CONCENTRATION:
FORMULATION:	Liquid. In 20mM TRIS, pH 7.4, containing 1.25M sodium chloride and 0.02% sodium azide.
IMMUNOGEN:	Recombinant human fibulin-1.
SPECIFICITY:	Recognizes human fibulin-1.
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections; paraffin sections) Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

Product Specific Literature References

Monoclonal antibody to fibulin-1 generated by genetic immunization: S.M. Pupa, et al.; J. Cell. Biochem. 89, 647 (2003) Abstract
Immunological and pathobiological roles of fibulin-1 in breast cancer: S.M. Pupa, et al.; Oncogene 23, 2153 (2004) Abstract

General Information

The fibulins are a family of secreted glycoproteins that are components of elastic matrix fibers and basement membranes. Fibulin-1 is an extracellular matrix protein, which can adhere to endothelial cells and regulate their motility and proliferation. Fibulin-1 is overexpressed in estrogen receptor (ER)-positive ovarian carcinomas and several studies suggest a possible role for fibulin-1 as a tumor suppressor. Xie et al. described that fibulin-1 inhibits tumor growth in HT1080 cell lines by suppressing tumor angiogenesis and inducing apoptosis.

General Literature References

Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth: L. Xie, et al.; Exp. Biol. Med. (Maywood) 233, 155 (2008) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies • Tumor Suppressors / Related Products

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