ALEXIS Biochemicals: Monoclonal Antibody to HSP27 (G3.1)

ALX-804-068

Revised 31-Aug-07

Monoclonal Antibody to HSP27 (G3.1)
SYNONYMS	anti-Heat Shock Protein 27 MAb (G3.1)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	Small Heat Shock Proteins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-068-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat Dog
CLONE:	G3.1
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Partially purified HSP27 (heat shock protein 27).
SPECIFICITY:	Recognizes human, mouse (weak), rat and dog HSP27. Detects a band of ~24kDa by Western blot.
APPLICATION:	ELISA Immunohistochemistry (paraffin sections (1:500)) Immunoprecipitation Western Blot (1:500)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Detection of a Mr 24,000 estrogen-related protein in human breast cancer by monoclonal antibodies: D.J. Adams, et al.; Cancer Res. 43, 4297 (1983) Abstract

General Information

HSP27 also referred to as the Estrogen-Regulated 24K protein and HSP28, is one of several small heat shock proteins (HSP) produced by all organisms studied. HSP27 synthesis is induced by elevated temperature, as well as estrogen in hormone responsive cells. Interestingly, human HSP27 also shares greater than 50% homology with low molecular weight Drosophila HSP's and mammalian a-crystalline lens protein. Because of the estrogen responsive nature of HSP27, this protein has been studied extensively in human estrogen responsive tissues such as cervix, endometrium and breast tissue. This work has led to the suggestion that HSP27 may be a useful marker in classifying various hormone sensitive tumors.

Further Categories Containing This Product:

Monoclonal Antibodies

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