ALEXIS Biochemicals: Monoclonal Antibody to HSP70 (BB70)

ALX-804-810

Revised 24-Mar-05

Monoclonal Antibody to HSP70 (BB70)
SYNONYMS	anti-Heat Shock Protein 70 MAb (BB70)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	HSP70 / DnaK / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-810-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Sheep Dog Pig Monkey Others
CLONE:	BB70
ISOTYPE:	Mouse IgG2a
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	>95% (SDS-PAGE)
FORMULATION:	Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Chicken HSP70 (heat shock protein 70)/HSP90 (heat shock protein 90) complex.
SPECIFICITY:	Recognizes both free and complexed human, mouse, rat, sheep, dog, pig, monkey, fish, guinea pig, hamster, rabbit, chicken, xenopus, drosophila and yeast HSP70 and HSC70. Detects bands of ~72 and ~73 kDa by Western blot, corresponding to HSP70 and HSC70, respectively.
APPLICATION:	Immunohistochemistry (works on endogenous) Immunoprecipitation (works on endogenous) Western Blot (works on endogenous)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least one year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70: D.F. Smith, et al.; Mol. Cell. Biol. 13, 869 (1993) Abstract; Full Text
Mutational analysis of the hsp70-interacting protein Hip: V. Prapapanich, et al.; Mol. Cell. Biol. 16, 6200 (1996) Abstract; Full Text
Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly: V. Prapapanich, et al.; Mol. Cell. Biol. 18, 944 (1998) Abstract; Full Text
Hop modulates Hsp70/Hsp90 interactions in protein folding: B.D. Johnson, et al.; J. Biol. Chem. 273, 3679 (1998) Abstract; Full Text
A role for heat shock protein 27 in CTL-mediated cell death: P.J. Beresford, et al.; J. Immunol. 161, 161 (1998) Abstract; Full Text
Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery: S. Chen & D.F. Smith; J. Biol. Chem. 273, 35194 (1998) Abstract; Full Text
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1: J. Zou, et al.; Cell 94, 471 (1998) Abstract; Full Text
Identification of genes that modify ataxin-1-induced neurodegeneration: P. Fernandez-Funez, et al.; Nature 408, 101 (2000) Abstract; Full Text
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents: R. Bagatell, et al.; Clin. Cancer Res. 6, 3312 (2000) Abstract; Full Text
Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes: D.L. Fisher, et al.; EMBO J. 19, 1516 (2000) Abstract
Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb: R. Mollaaghababa, et al.; PNAS 98, 3958 (2001) Abstract; Full Text
Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1: G. Marchler & C. Wu; EMBO J. 20, 499 (2001) Abstract
Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase: H. Sakahira & S. Nagata; J. Biol. Chem. 277, 3364 (2002) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome: J. Luders, et al.; J. Biol. Chem. 275, 4613 (2000) Abstract; Full Text

Further Categories Containing This Product:

Endoplasmatic Reticulum Stress • Monoclonal Antibodies

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