ALEXIS Biochemicals: Monoclonal Antibody to HSP90 Co-chaperone (JJ3)

ALX-804-023

Revised 01-Oct-08

Monoclonal Antibody to HSP90 Co-chaperone (JJ3)
SYNONYMS	anti-Telomerase-binding Protein p23 MAb (JJ3) anti-Progesterone Receptor Complex p23 MAb (JJ3)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	HSP90 / HtpG / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-023-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Others
CLONE:	JJ3
ISOTYPE:	Mouse IgG2a
FORMULATION:	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Recombinant human HSP90 Co-chaperone.
SPECIFICITY:	Recognizes human, mouse, chicken, rabbit and guinea pig HSP90 Co-chaperone. Detects a band of ~23kDa by Western blot.
APPLICATION:	Immunocytochemistry Immunoprecipitation (use on free or complexed HSP90 Co-chaperone) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation.: K.D. Dittmar & W.B. Pratt; J. Biol. Chem. 272, 13047 (1997) Abstract
Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids: J.Hu, D. O. Toft & C. Seeger; EMBO Journal 16, 59 (1997) Full Text

General Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex.
Cloned human p23 encodes a protein of 160 aa that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.

Further Categories Containing This Product:

Chaperone-mediated Autophagy [CMA] • Monoclonal Antibodies

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.