ALEXIS Biochemicals: Monoclonal Antibody to LTβR (mouse) (4H8 WH2)

ALX-804-145

Revised 29-Feb-08

Monoclonal Antibody to LTβR (mouse) (4H8 WH2)
SYNONYMS	anti-Lymphotoxin-β Receptor (mouse) MAb (4H8 WH2) anti-Tumor Necrosis Factor Receptor 2 related Protein (mouse) MAb (4H8 WH2) anti-Tumor Necrosis Factor C Receptor (mouse) MAb (4H8 WH2) anti-TNFRSF 3 (mouse) MAb (4H8 WH2) anti-Tumor Necrosis Factor Receptor Superfamily Member 3 [Precursor] (mouse) MAb (4H8 WH2)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	HVEM & LIGHT / LT-betaR / DcR3 / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-145-C100		100 µg	325.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	4H8 WH2
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
PURITY:	≥98% (SDS-PAGE)
FORMULATION:	Liquid. In PBS.
IMMUNOGEN:	Recombinant mouse LTβR cysteine-rich region (aa 31-221).
SPECIFICITY:	Recognizes mouse LTβR.
APPLICATION:	Flow Cytometry Functional Application (agonist inducing BAFF, chemokines and integrins in vitro and in vivo)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

Product Description

The monoclonal antibody to mouse LTβR is an agonist that can be used for the investigation of the regulation of BAFF(BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells, and NK T cells, to study the regulation of NF-κB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-κB2 pathway.
For use as an agonist the MAb to LTβR is added to cell cultures at 2µg/ml. For in vivo use, mice are injected intraperitoneally with 50µg of agonistic MAb to LTβR in sterile phosphate saline.

Product Specific Literature References

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002) Abstract
Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors: B. Silva-Santos, et al.; Science 307, 925 (2005) Abstract

General Information

The LTβR activates two different NF-κB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTβR activates the classical NF-κB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1β. However, LTβR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression: W.R. Force, et al.; J. Immunol. 155, 5280 (1995) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.