ALEXIS Biochemicals: Monoclonal Antibody to Laminin (α4-chain) (human) (651C2)

ALX-803-310

Revised 17-Apr-08

Monoclonal Antibody to Laminin (α4-chain) (human) (651C2)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	Laminin / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-310-R100		100 µl	310.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	651C2
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. Ascites.
IMMUNOGEN:	Recombinant human laminin α4 subunit (G1-G3 domains).
SPECIFICITY:	Recognizes an epitope within the G1-G3 domains of human laminin α4 subunit.
APPLICATION:	ELISA (1:500-1:2’000) Immunohistochemistry (frozen sections (1:100-1:300))
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Laminin isoforms 8 and 10 are primary components of the subendothelial basement membrane promoting interaction with neoplastic lymphocytes: P. Spessotto, et al.; Cancer Res. 61, 339 (2001) Abstract; Full Text

General Information

The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every tissue. Each laminin is a heterotrimer assembled from α, β and γ chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycans, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, cell shape and movement, maintenance of tissue phenotypes and promotion of tissue survival.

General Literature References

Form and function: the laminin family of heterotrimers: H. Colognato & P.D. Yurchenko; Dev. Dyn. 218, 213 (2000), (Review) Abstract; Full Text
Laminin: the crux of basement membrane assembly: T. Sasaki, et al.; J. Cell. Biol. 164, 959 (2004), (Review) Abstract; Full Text
Laminin-induced signaling in tumor cells: V. Givant-Horwitz, et al.; Cancer Lett. 223, 1 (2005), (Review) Abstract
Physiological and pathological implications of laminins: from the gene to the protein: M.C. Paez, et al.; Autoimmunity 40, 83 (2007), (Review) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.