ALEXIS Biochemicals: Monoclonal Antibody to Laminin (γ1-chain) (human) (LN82-13)

ALX-804-195

Revised 17-Apr-08

Monoclonal Antibody to Laminin (γ1-chain) (human) (LN82-13)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	Laminin / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-195-C100		100 µg	390.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	LN82-13
ISOTYPE:	Mouse IgG1
CONCENTRATION:	2mg/ml after reconstitution.
PURITY DETAIL:	Purified by ammonium sulfate fractionation and ion-exchange chromatography.
FORMULATION:	Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:	Reconstitute with 50µl distilled water.
IMMUNOGEN:	Human laminin.
SPECIFICITY:	Recognizes human γ1-chain of laminin fragment P1 and P2.
APPLICATION:	ELISA: Sandwich immunoassay is possible by combination of clone LN82-13 (Prod. No. ALX-804-195) (capture antibody) and clone LN41-11 (Prod. No. ALX-804-194) (detection antibody, when labelled). Immunohistochemistry (frozen sections) Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Specific Literature References

Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains: T. Geberhiwot, et al.; Matrix Biol. 19, 163 (2000) Abstract

General Information

The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every tissue. Each laminin is a heterotrimer assembled from α, β and γ chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycans, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, cell shape and movement, maintenance of tissue phenotypes and promotion of tissue survival.

General Literature References

Form and function: the laminin family of heterotrimers: H. Colognato & P.D. Yurchenko; Dev. Dyn. 218, 213 (2000), (Review) Abstract; Full Text
Laminin: the crux of basement membrane assembly: T. Sasaki, et al.; J. Cell Biol. 164, 959 (2004), (Review) Abstract; Full Text
Laminin-induced signaling in tumor cells: V. Givant-Horvitz, et al.; Cancer Lett. 223, 1 (2005), (Review) Abstract
Physiological and pathological implications of laminins: from the gene to the protein: M.C. Paez, et al.; Autoimmunity 40, 83 (2007), (Review) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.