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ALX-804-620 Revised 21-Oct-08
Monoclonal Antibody to Laminin Receptor Precursor (37kDa) (human) (MPLR2)
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SYNONYMS anti-37-kDa Laminin Receptor Precursor (human) MAb (MPLR2)
anti-37LRP (human) MAb (MPLR2)
anti-p40 Ribosome-associated Protein (human) MAb (MPLR2)
anti-Multidrug Resistance-associated Protein MGr1-Ag (human) MAb (MPLR2)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Laminin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-620-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MPLR2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody containing 150mM sodium chloride and 0.02% sodium azide, pH 7.4.
IMMUNOGEN: Recombinant human 37kDa-laminin receptor precursor (37LRP).
SPECIFICITY: Recognizes human 37kDa laminin receptor precursor. Depending on solubilization, can also recognize the 67kDa mature form of the laminin receptor (67LR) (see [1]). Detects a band of ~37kDa by Western blot.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
[1] Production and characterization of monoclonal antibodies directed against the laminin receptor precursor: S. Buto, et al.; Int. J. Biol. Markers 12, 1 (1997) Abstract
[2] Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin: E. Ardini, et al.; J. Biol. Chem. 272, 2342 (1997) Abstract
[3] Formation of the 67-kDa laminin receptor by acylation of the precursor: S. Buto, et al.; J. Cell. Biochem. 69, 244 (1998) Abstract
[4] Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins: M. Vivinus-Nebot, et al.; J. Cell Biol. 144, 563 (1999) Abstract
[5] Human recombinant laminin-binding protein: isolation, purification, and crystallization: A.V. Sorokin, et al.; Biochemistry (Mosc). 65, 546 (2000) Abstract
General Information
The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. They are mediated by different cell surface molecules such as the 67kD laminin receptor (67LR; laminin receptor 1), a protein derived from a smaller precursor, the 37LRP. In addition to its role as laminin receptor, 67LR also acts as a receptor for viruses and is involved with internalization of the prion protein.
General Literature References
The 67 kDa laminin receptor: structure, function and role in disease: J. Nelson, et al.; Biosci. Rep. 28, 33 (2008) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Prion Protein / Related Products • Tumor Markers
 
 
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