ALEXIS Biochemicals: Monoclonal Antibody to RIG-I (Alme-1)

ALX-804-849

Revised 16-Aug-07

Monoclonal Antibody to RIG-I (Alme-1)
SYNONYMS	anti-RIG-1 MAb (Alme-1) anti-Retinoic Acid-inducible Gene 1 Protein MAb (Alme-1) anti-DEAD-box Protein 58 MAb (Alme-1) anti-Probable ATP-dependent RNA Helicase DDX58 MAb (Alme-1)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	RNA Helicases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-849-C100		100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	Alme-1
ISOTYPE:	Mouse IgG1
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).
SPECIFICITY:	Recognizes human and mouse RIG-I.
APPLICATION:	Immunohistochemistry (paraffin sections) Immunoprecipitation (1:100) Western blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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General Information

RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Virology. Sensing viral RNA amid your own: T. Fujita; Science 314, 935 (2006) Abstract
5’-Triphosphate RNA is the ligand for RIG-I: V. Hornung, et al.; Science 314, 994 (2006) Abstract
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates: A. Pichlmair, et al.; Science 314, 997 (2006) Abstract

Related Products

ALX-210-932	Polyclonal Antibody to RIG-I (human) (AT111)
ALX-840-609	Positive Control (Cell Lysate) for Antibodies to RIG-I (human)
APO-54N-038	RIG-I (human) (IntraCellular) Detection Set [For ELISA Application]

Further Categories Containing This Product:

NF-kB Pathway Other Products • Antiviral Signalling / Related Products • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products • Polyclonal Antibodies

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