ALEXIS Biochemicals: Monoclonal Antibody to RUNX3 (human) (R3-6E9)

ALX-803-318

Revised 24-Apr-08

Monoclonal Antibody to RUNX3 (human) (R3-6E9)
SYNONYMS	anti-Runt-related Transcription Factor 3 (human) MAb (R3-6E9) anti-CBF-α3 (human) MAb (R3-6E9) anti-Core-binding Factor α3 Subunit (human) MAb (R3-6E9) anti-AML-2 (human) MAb (R3-6E9) anti-Acute Myeloid Leukemia 2 Protein (human) MAb (R3-6E9)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Transcription Factors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-318-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	R3-6E9
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300).
SPECIFICITY:	Recognizes human RUNX3. Weakly cross-reacts with mouse RUNX3.
APPLICATION:	Immunohistochemistry (paraffin sections (2µg/ml)) (see [1]) Immunoprecipitation Western Blot (0.2µg/ml (see [1]))
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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Product Specific Literature References

[1] RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization: K. Ito, et al.; Cancer Res. 65, 7743 (2005) Abstract; Full Text
[2] RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer: Q.C. Lau, et al.; Cancer Res. 66, 6512 (2006) Abstract; Full Text
[3] Targets of genome copy number reduction in primary breast cancers identified by integrative genomics: W. Chen, et al.; Genes Chromosomes Cancer 46, 288 (2007) Abstract

General Information

RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells.

General Literature References

Tumor suppressor activity of RUNX3: S.C. Bae & J.K. Choi; Oncogene 23, 4336 (2004) Abstract
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis: T. Yano, et al.; Mol. Cell. Biol. 26, 4474 (2006) Abstract; Full Text

Further Categories Containing This Product:

Monoclonal Antibodies • Tumor Suppressors / Related Products

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