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Growth, Survival and Development of Neurons
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ALX-522-135 Revised 05-May-08
CDNF (human) (recombinant)
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SYNONYMS Conserved Dopamine Neurotrophic Factor (human) (recombinant)
ARMEL (human) (recombinant)
ARMET-like Protein 1 Precursor (human) (recombinant)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neurotrophic Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-135-C010   10 µg 390.00 USD Add To Cart
Product Specification
MW: ~16kDa
SOURCE/HOST: Produced in E. coli. Human CDNF (conserved dopamine neurotrophic factor) (aa 27-187).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Human CDNF encodes a 187 amino acid protein with predicted signal peptides. In mouse, it is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q49AH0: CDNF (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo: P. Lindholm, et al.; Nature 448, 73 (2007) Abstract
Related Products
Further Categories Containing This Product:
Parkinson's Disease Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-133 Revised 31-Mar-08
CDNF (mouse) (recombinant)
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SYNONYMS Conserved Dopamine Neurotrophic Factor (mouse) (recombinant)
ARMEL (mouse) (recombinant)
ARMET-like Protein 1 Precursor (mouse) (recombinant)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neurotrophic Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-133-C010   10 µg 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~16kDa
SOURCE/HOST: Produced in E. coli. Untagged mouse CDNF (aa 27-187).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Mouse CDNF encodes a 187 amino acid protein with predicted signal peptides. It is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8CC36: CDNF (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.: P. Lindholm, et al.; Nature 448, 73 (2007) Abstract
Related Products
Further Categories Containing This Product:
Parkinson's Disease Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-109 Revised 14-Apr-08
DCC (Fibronectin Domain 5) (human) (recombinant)
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SYNONYMS Deleted in Colorectal Cancer Protein (Fibronectin Domain 5) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-109-C050   50 µg 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The fibronectin domain 5 (FBN5) of human DCC (aa 841-941) is fused to a N-terminal tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human netrin-1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer: J. Fitamant, et al.; PNAS 105, 4850 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q16218: Deleted in Colorectal Cancer Protein (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin: B.V. Geisbrecht, et al.; J. Biol. Chem. 278, 32561 (2003) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Fibronectin / Related Products
 
 
ALX-804-853 Revised 05-Jan-09
Monoclonal Antibody to DCC (human) (Axel-1)
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SYNONYMS anti-Deleted in Colorectal Cancer Protein (human) MAb (Axel-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-853-C100   100 µg 340.00 USD Add To Cart
ALX-804-853PF-C100 Preservative Free 100 µg 340.00 USD Add To Cart
ALX-804-853TD-T100 ATTO 488 100 tests 380.00 USD Add To Cart
ALX-804-853TS-T100 ATTO 647N 100 tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Axel-1
ISOTYPE: Mouse IgG2aλ
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: ALX-804-853: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853PF: Liquid. In PBS.
ALX-804-853TD: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853TS: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human DCC fibronectin domain 5 (Prod. No. ALX-522-109).
SPECIFICITY: Recognizes human DCC.
APPLICATION: Flow Cytometry
Functional Application: Blocking
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
BACKGROUND/TECHNICAL INFORMATION 1 test means: 1µl of MAb is used to stain 500’000 cells in a sample volume of 50µl.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-574 Revised 25-Oct-05
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (MGR15)
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SYNONYMS anti-NGFR (human) MAb (MGR15)
anti-TNFRSF 16 (human) MAb (MGR15)
anti-p75NTR (human) MAb (MGR15)
anti-p75 Neurotrophin Receptor (human) MAb (MGR15)
anti-CD271 (human) MAb (MGR15)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (MGR15)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-574-C050   50 µg 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MGR15
ISOTYPE: Mouse IgM
CONCENTRATION: 0.4mg/ml
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1.25M sodium chloride and 0.02% sodium azide.
IMMUNOGEN: SKNBE neuroblastoma cell line transfected with human NGFR (nerve growth factor receptor; p75NTR).
SPECIFICITY: Recognizes an epitope present in the extracellular domain of human NGFR.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
General Literature References
Trk receptors: roles in neuronal signal transduction: E.J. Huang, et al.; Annu. Rev. Biochem. 72, 609 (2003) Abstract
Neurotrophin signaling through the p75 neurotrophin receptor: P.P. Roux, et al.; Prog. Neurobiol. 67, 203 (2002) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-833 Revised 21-Dec-06
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (Nagy-1)
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SYNONYMS anti-NGFR (human) MAb (Nagy-1)
anti-TNFRSF 16 (human) MAb (Nagy-1)
anti-p75NTR (human) MAb (Nagy-1)
anti-p75 Neurotrophin Receptor (human) MAb (Nagy-1)
anti-CD271 (human) MAb (Nagy-1)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (Nagy-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-833-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nagy-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human NGFR (nerve growth factor receptor; p75NTR):Fc (Prod. No. ALX-522-044).
SPECIFICITY: Recognizes human NGFR.
APPLICATION: Flow Cytometry (1:1'000)
Immunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells: A. Tanaka, et al.; BBRC 313, 1009 (2004) Abstract
p75NTR--live or let die: A. Nykjaer, et al.; Curr. Opin. Neurobiol. 15, 49 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-838 Revised 02-Jul-07
Monoclonal Antibody to Netrin-1 (Nora-1)
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SYNONYMS anti-Netrin-1 MAb (Nora-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-838-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Nora-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human, mouse and chicken netrin-1 (aa 28-264).
SPECIFICITY: Recognizes human, mouse and chicken netrin-1.
APPLICATION: ELISA
Immunohistochemistry
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL: Prod. No. ALX-522-100
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis: L. Mazelin, et al.; Nature 431, 80 (2004) Abstract
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-860 Revised 12-Dec-07
Monoclonal Antibody to Netrin-4 (human) (Netry-1)
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SYNONYMS anti-β-Netrin (human) MAb (Netry-1)
anti-Hepar-derived Netrin-like Protein (human) MAb (Netry-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-860-C100   100 µg 360.00 USD Add To Cart
ALX-804-860B-C100 Biotin 100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Netry-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-862 Revised 28-May-08
Monoclonal Antibody to Netrin-4 (Netry-2)
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SYNONYMS anti-β-Netrin MAb (Netry-2)
anti-Hepar-derived Netrin-like Protein MAb (Netry-2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-862-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Netry-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human netrin-4 (Prod. No. ALX-522-113).
SPECIFICITY: Recognizes human and mouse netrin-4.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1´000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-522-113
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies