ALX-522-140 IL-35 (human):Fc (human) (recombinant)
IL-35 (interleukin-35) is a heterodimeric cytokine from the IL-12 family composed of EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35) involved in T cell regulation. IL-35 is highly expressed in regulatory T cell (Treg) but not in effector or naive T cells. IL-35 is required for the suppressive function of T-reg in vitro and in vivo.
LIT: The inhibitory cytokine IL-35 contributes to regulatory T-cell function: L.W. Collison, et al. ; Nature 450, 566 (2007)
AG-R0822 RBP4 (human) Sandwich ELISA Kit
Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues. In obesity and type 2 diabetes, RBP4 plays a role in regulating insulin. Thus, measurement of serum or plasma RBP4 is a useful means for understanding metabolic disorders.
This kit is an enzyme-linked immunosorbent assay (ELISA) for quantitative determination of RBP4 in human serum, plasma or cell culture supernatants.
LIT: Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein: L. Quadro, et al. ; EMBO J. 18, 4633 (1999) • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes : Q. Yang, et al.; Nature 436, 356 (2005)
Related Products: RBP4 (human) Competitive ELISA Kit
- Download the Angiopoietin Flyer as PDF.
New human ANGPTL6 ELISA Kit
AG-A0722 ANGPTL6 (human) ELISA Kit
Angiopoietin-like protein 6 (ANGPTL6) is a hepatocyte-derived circulating factor that counteracts obesity and obesity-related insulin resistance, hence, ANGPTL6 may be a novel biomarker for metabolic diseases.
This kit is an enzyme-linked immunosorbent assay (ELISA) for quantitative determination of ANGPTL6 in human serum, plasma or cell culture supernatants.
New human ILEI Detection Set
APO-54N-032 ILEI (human) Detection Set [For ELISA Application]
ILEI (Interleukin-like EMT-inducer, also called FAM3C) is a new secreted cytokine-like protein of 25 kDa that has structural homology to four-helix-bundle cytokines such as erythropoietin, growth hormone or interleukin members. Recently, ILEI has been identified as a key player in epithelial-to-mesenchymal transition (EMT), in carcinoma progression as well as in metastasis which acts downstream of TGFβ receptor signaling. ILEI expression is increased in many carcinomas and could serve as an independent prognostic marker in breast cancer. ILEI is also secreted by pancreatic cancer cells.
This assay is a sandwich enzyme linked-immunosorbent assay (ELISA) developed for the direct measurement of human ILEI in biological fluids.
LIT: Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers: T. Waerner, et al.; FASEB J. 19, 1125 (2005) • ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) • Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach: M. Gronborg, et al; Mol. Cell. Proteomics 5, 157 (2006)
New human Netrin-4 Detection Set
APO-54N-033 Netrin-4 (human) Detection Set [For ELISA Application]
The Netrins (whose name means “one who guides” in Sanskrit) constitute a family of laminin-related secreted proteins. They are involved in axonal guidance, are required for regeneration and maintenance of the central nervous system and have been implicated in the development of mammary gland, lung, pancreas, and blood vessels. Netrin-4 acts during the development and controls the migration of neurons. It promotes angiogenesis by stimulating proliferation and migration of microvascular endothelial and has been reported to be a novel prognostic marker in breast cancer.
This assay is a sandwich enzyme linked-immunosorbent assay (ELISA) developed for the direct measurement of human Netrin-4 in biological fluids.
LIT: Netrins promote developmental and therapeutic angiogenesis: B.D. Wilson, et al.; Science 313, 640 (2006) • Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins: S. Esseghir, et al.; Clin. Cancer Res. 13, 3164 (2007)
New human WIPI-1 Antibody
ALX-210-954 Polyclonal Antibody to WIPI-1 (human) (AT129)
WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
LIT: Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007)
Related Product: Polyclonal Antibody to WIPI-1 (AT130)
New cooling agent WS-12
ALX-420-041 WS-12
WS-12 is a cooling agent acting as agonist with high-affinity for TRPM8 (cold menthol receptor 1; CMR1). It has an EC50 value which is ~2’000 times lower than that of menthol.
Related Products: Icilin, (-)-Menthol
LIT: Characterisation of TRPM8 as a pharmacophore receptor: M. Bodding, et al.; Cell Calcium 42, 618 (2007)
New mouse Collectrin Antibody
ALX-803-322 Monoclonal Antibody to Collectrin (mouse) (2G5)
Collectrin is a homolog of angiotensin-converting enzyme 2 (ACE2). It has an apparent signal peptide and a transmembrane domain but lacks active dipeptidyl carboxypeptidase catalytic domains. The sequence is conserved in mouse, rat, and human. Collectrin is a regulator of renal aa uptake and may provide a molecular explanation for aminoaciduria in Hartnup disease, Fanconi syndrome, or diabetes. Mechanistically, collectrin associates with several aa transporters, enhances their surface expression, and thereby increases aa transport function. Collectrin favours the formation of SNARE complexes and controls insulin exocytosis.
LIT: Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys: H. Zhang, et al.; J. Biol. Chem. 276, 17132 (2001) • The HNF-1alpha-SNARE connection: K. Yamagata, et al.; Diabetes Obes. Metab. 9, 40 (2007)
New inhibitors of DGAT: Amidepsines
ALX-380-262 Amidepsine A
ALX-380-263 Amidepsine D
Amidepsines are inhibitors of diacylglycerol acyltransferase (DGAT). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Amidepsin A Amidepsin D
LIT: Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) • Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995)
New agonist of motilin receptor: EM574
ALX-380-264 EM574
EM574 is a agonist of the motilin receptor which shows antimicrobial and gastrointestinal motor stimulating activity in vivo.
LIT: EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M.Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) • Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. 49, 794 (1996)
Related Product: Erythromycin
New inhibitor of HMG-CoA synthase: Hymeglusin
ALX-380-265 Hymeglusin
HMG-CoA synthase is an enzyme which catalyzes the reaction where Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Hymeglusin specifically and irreversibly inhibits HMG-CoA synthase and hence inhibits mevalonate biosynthesis. Additionally, it shows antimicrobial and antifungal activity.
LIT: F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase: H. Tomoda, et al.; Biochim. Biophys. Acta 922, 351 (1987)
New inhibitor of Syk: BAY 61-3606
ALX-270-479 BAY 61-3606 . hydrochloride
BAY 61-3606 is a cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). It is highly selective if compared to other kinases and shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM.
LIT: The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY61-3606) blocks antigen-induced airway inflammation in rodents: N. Yamamoto, et al.; J. Pharmacol. Exp.Ther. 306, 1174 (2003) • A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells: K. Nakashima, et al.; Eur. J. Pharmacol. 505, 223 (2004)
New immunosuppressor: FTY720
ALX-420-043 FTY720
FTY720 is an analog of myriocin. It is a novel immune modulator that alters migration and homing of lymphocytes and acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Additionally, FTY720 inhibits cytosolic phospholipase A2 independently of S1P
LIT: The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol.Chem. 277, 21453 (2002) • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007)
Related Product: Myriocin
